In Ephesians 5, Paul is giving a series of practical exhortations about maintaining stability in the Christian life. He describes it as a deliberate walking away from evil practices and purposely investing in those things that will prepare us to stand up and count for Christ. In the middle of chapter 5 he states:
15 Look carefully then how you walk, not as unwise but as wise, 16 making the best use of the time, because the days are evil. 17 Therefore do not be foolish, but understand what the will of the Lord is. 18 And do not get drunk with wine, for that is debauchery, but be filled with the Spirit, 19 addressing one another in psalms and hymns and spiritual songs, singing and making melody to the Lord with your heart, 20 giving thanks always and for everything to God the Father in the name of our Lord Jesus Christ, 21 submitting to one another out of reverence for Christ.
At first glance, the first verses sound like "playing it safe/avoiding all risks." But in reality they are saying don't take foolish risks. Wisdom is always called for. Knowing God's will is crucial. Staying in tune with the Holy Spirit for direction is imperative. Fellowship with other believers who help one another confirm what we believe God is calling us to - no matter how humanly crazy it may seem - is priceless. God's Word, Spirit, and people all will keep us in position to take risks that will bring glory to God.